The University of Cambridge is consistently ranked among the foremost universities in the world. Work will be carried out in the Computer Laboratory. The Computer Laboratory is the University of Cambridge's Computer Science department. The Computer Laboratory was founded in 1937 with pioneering works in building complete computers (the EDSAC was commissioned in 1949 and the EDSAC 2 in 1958). Former members of the department have introduced in Computer Science the ASCII code, the concept of subroutine, the pi calculus and several programming languages such as C++. The Cambridge Diploma in Computer Science was the world's first taught course in computing, starting in 1953. The University of Cambridge has an extremely active PhD program, with many regular seminar and journal club programmes covering methodologies and practice, talks given by international speakers and forum that encourages collaborations, networking, research and industry interactions between the local bioinformatics and associated research community. In particular : The Cambridge Infectious Disease in the Veterinary dept; Behaviour, Ecology & Evolution Seminar Series in the Dept of Zoology, Structural seminars at Laboratory of Molecular Biology, Bioinformatics seminars at the European Bioinformatics Institute, Protein communication and Signalling at Brabaham Institute. UCAM ESRs will be able to attend bioinformatics courses provided via the Cambridge Systems Biology Centre (PartIII Systems Biology), the Department of Maths & Theoretical Physics (MSc Computational Biology) and the Department of Computer Science (MPhil in advanced computing). Pietro Lio’ teaches Bioinformatics Algorithms in the Computer Laboratory, Biomedical Informatics (MPhil in advanced Computing), Mathematical modelling of diseases (MPhil in Computational Biology) and in the Part III systems Biology. Due to the rich and diverse scientific community in Cambridge there will be opportunity to attend a wide range of formal and informal training available in methodologies relevant to the project.